Journal: Frontiers in Molecular Biosciences
Article Title: Nicotinic acetylcholine receptor-mediated effects of varenicline on LPS-elevated prostaglandin and cyclooxygenase levels in RAW 264.7 macrophages
doi: 10.3389/fmolb.2024.1392689
Figure Lengend Snippet: Effects of varenicline on LPS-induced COX and PG elevations in the presence or absence of nAChR antagonists. Shown are 1 μg/mL LPS-elevated COX-1 (A) ; COX-2 (B) , PGE2 (C) , 6-keto PGF1α (D) and TXA2 (E) levels in the absence or presence of varenicline (VAR, 1 μΜ), mecamylamine (MEC, 50 μΜ) and methyllycaconitine (MLA, 1 μΜ). Data are shown as mean ± S.E.M. (***, p < 0.001 vs. control, ††† , p < 0.001 vs. LPS; ‡ , p < 0.05, ‡‡ , p < 0.01, ‡‡‡ , p < 0.001 vs. LPS + VAR, n = 6, One-way ANOVA with post hoc Tukey-Kramer multiple comparison test or Student’s t- test). LPS: Lipopolysaccharide, VAR: Varenicline, MLA: Methylylcaconitine citrate, MEC: Mecamylamine. COX: Cyclooxygenase, PGE2: Prostaglandin E2, TXA2: Thromboxane A2.
Article Snippet: One-way analysis of variance analysis (ANOVA) with post hoc Tukey-Kramer multiple comparison tests or Student’s t -test (GraphPad Prism 5, La Jolla, CA) were used to compare means to compare means of data distributed parametrically.
Techniques: Control, Comparison